2 edition of Regulation of growth of normal and preneoplastic mammary epithelium by mammary adipose tissue found in the catalog.
Regulation of growth of normal and preneoplastic mammary epithelium by mammary adipose tissue
James Christopher Beck
Written in English
|Statement||James Christopher Beck.|
|The Physical Object|
|Pagination||x, 79 leaves, bound :|
|Number of Pages||79|
The tumors were classified into basal-like, HER2/neu over expressing, luminal-like types, and normal breast tissue–like subgroup. The normal breast-like subtype originally proposed has since been recognized as probably arising from normal-tissue contamination (95, , , ). The most well-characterized and widely accepted molecular Cited by: Abstract. The vitamin D 3 receptor (VDR) is a ligand-dependent transcription factor implicated in regulation of cell cycle, differentiation and apoptosis of both normal and transformed cells derived from mammary gland. In these studies we examined whether VDR status altered mammary gland morphology or transformation in the well-characterized MMTV-neu transgenic model of breast Cited by:
The mammary fat pad is essential for developmentof the mammary epithelium, providing signals thatmediate ductal morphogenesis and, probably, alveolardifferentiation. The “cleared” fat pad is often used as a transplantation ering the crucial role of the fat pad, itsproperties have received relatively little attentionfrom researchers in the field. Some of the questionswhose. The total absence of white adipose tissue in the mammary gland disrupts stromal-epithelial interactions and prevents normal mammary gland development,. Thus, when investigating the development or homeostasis of the mammary epithelium, it is necessary to consider all microenvironments of the mammary by:
A dense stroma layer was formed around mammary epithelial structures, and a fibroblastic stroma replaced the normal adipose tissue of the mammary gland exhibited by controls. The presence of such fibroblastic-like stroma, which also includes inflammatory cells, indicates a Cited by: The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating from 40 different women and comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quantitated in situ and expressed as population-doubling by:
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In the mouse, mammary epithelium is embedded within an adipose "fat pad"; normal and preneoplastic mammary epithelium will grow in vivo only if embedded in such a fat pad (10,19,20). We have attempted to discern if intact mammary fat pad pieces or isolated fat pad adipose cells could exert such a growth regulatory effect on mammary epithelium.
We investigated the effects of conditioned media derived from mouse mammary fat pads on the proliferation of CL-S1 cells, an epithelial cell line originally isolated from a preneoplastic mammary outgrowth line.
Cell proliferation in vitro in serum-free defined medium was compared to that in this medium conditioned using intact mammary fat pad pieces or isolated fat pad by: The mammary gland consists of an adipose tissue that, in a process called branching morphogenesis, is invaded by a ductal epithelial network comprising basal and luminal epithelial cells.
Stem and progenitor cells drive mammary growth, and their proliferation is regulated by multiple extracellular by: Vonderhaar B.K. () Regulation of development of the normal mammary gland by hormones and growth factors. In: Lippman M.E., Dickson R.B. (eds) Breast Cancer: Cellular and Molecular Biology.
Cancer Treatment and Research, vol Cited by: The growth and morphogenesis of mammaryparenchyma varies substantially between species and isregulated by an array of systemic and local l to this regulation is the mammary fat pad, amatrix of adipose and connective tissue capable ofmediating hormone action and synthesizing an array ofgrowth regulatory molecules.
In this article wehighlight differences between Cited by: Eur J Ca- C(in Orscal, Vol. 21, No. 12, pp. _, Printed in Great Britain. /85E+ Perqamon Press Ltd. Suppression of Normal and Preneoplastic Mammary Growth and Uterine Adenomyosis with Reduced Growth Hormone Level in SHN Mice Given Monosodium Glutamate Neonatally* HIROSHI NAGASAWA,t+ YUUJI NOGUCHI,fi TAKAO Cited by: The growth and morphogenesis of mammaryparenchyma varies substantially between species and isregulated by an array of systemic and local l to this regulation is the mammary fat pad, amatrix of adipose and connective tissue capable ofmediating hormone action and synthesizing an array ofgrowth regulatory molecules.
In this article wehighlight differences between. The concentration of Ca++ in culture media profoundly affected the growth and differentiation properties of normal human mammary epithelial cells in short-term culture.
In media where Ca++ was above mM, longevity was limited to an average of three to four cell divisions. The extended growth fraction (those cells able, to divide more than once) was only approximately 50% Cited by: HOX genes in normal and neoplastic mouse mammary gland sites, requiring mammary adipose tissue.
of the tyrosine kinase iyk in the normal human breast epithelium and loss of expression. The mammary fat pad is essential for developmentof the mammary epithelium, providing signals thatmediate ductal morphogenesis and, probably, alveolardifferentiation. The “cleared” fat pad is often used as a transplantation ering the crucial role of the fat pad, itsproperties have received relatively little attentionfrom researchers in the by: An epithelial cell line, designated COMMA-1D, was derived from mammary tissue of BALB/c mice in the middle of pregnancy.
This line, in continuous cell culture for 12 months, exhibits several. Central to this regulation is the mammary fat pad, a matrix of adipose and connective tissue capable of mediating hormone action and synthesizing an array of growth regulatory molecules.
Normal growth regulation The development of in vitro systems including murine mammary explant culture, whole murine mammary gland culture and human mammary epithelial cell cul- ture have greatly assisted analysis of the growth require- ments for development of normal breast by: 9.
Abstract. A novel system is described for studying the growth of normal human mammary epithelium in vivo as grafts in athymic nude mice. The key feature of this model is reconstitution of the epithelial-stromal interactions required for normal growth and differentiation of the human mammary epithelium, which produces ducts that are comparable to those in the normal human mammary Cited by: The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad.
As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and.
Imagawa W, Tomooka Y, Nandi S. Serum-free growth of normal and tumor mouse mammary epithelial cells in primary culture. Proc Natl Acad Sci U S A. Jul; 79 (13)– [PMC free article] Wicha MS, Lowrie G, Kohn E, Bagavandoss P, Mahn T. Extracellular matrix promotes mammary epithelial growth and differentiation in by: Introduction.
Any discussion of processes involving mammary gland growth, differentiation, lactation or involution is generally centered about changes within the epithelial tissue [1–3].However, a unique and fascinating aspect of mammary gland biology is the requirement for mammary epithelial cells to grow and function in a stromal environment referred to as the mammary Cited by: The adult mammary gland is a bilayered branching epithelial structure consisting of an outer layer of basal cells and an inner layer of luminal cells.
The neonatal structure expands rapidly during puberty and then undergoes cyclic growth in response to the changing hormonal stimuli (progesterone and estrogen) in each menstrual cycle ([ 1 ]). These dynamic responses of the mammary Cited by: 4.
Considering that the human breast is a more fibrous tissue than is the adipose-rich stroma of the murine mammary gland, our group sought to bypass the effects of the rodent microenvironment Cited by: Growth factor dependency and gene expression in preneoplastic mouse mammary epithelial cells.
[D Medina, F S Kittrell, C J Oborn, M Schwartz] PMID Abstract The TM preneoplastic mammary outgrowth lines were established in vivo from mammary epithelial cell lines and have been characterized with respect to their tumorigenic.
Beck, J., Hosick, H., and Watkins, B.: Growth of Epithelium From a Preneoplastic Mammary Outgrowth on Response to Mammary Adipose Tissue, In Vitro Cell Dev Biol 25 (5),Mouse Epithelial.Diverse relationships between adipose tissue and the mammary epithelium.
a and b) Photomicrographs of epithelial ducts within the #3 thoracic mammary glands from the same pubescent female Balb/C.Keratinocyte growth factor is a growth factor for mammary epithelium in vivo: The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.